Curcumin containing soft liner as an alternative treatment modality for oral candidiasis

Abstract

Aim and objective: Recently, herbal treatment has been validated to be a safe and effective alternative to antimicrobial drugs since it has minimal or no complications. Consequently, this study was conducted to evaluate the antifungal activity of soft liner/curcumin formulation considering its surface roughness, and tensile bond strength to the denture base. Materials and methods: Ethanolic extract of curcumin was prepared in a concentration of 10%. The curcumin solution was blended with the soft liner liquid in ratios of 10 and 20 v/v%. Two experimental groups were considered besides the control (unmodified liner). A total number of 90 specimens was prepared for evaluating antifungal activity, surface roughness, and tensile bond strength of the modified soft liner to the denture base resin. ANOVA and Tukey post hoc tests were used for the statistical analysis at a level of significance of 0.05. Results: 20 v/v% curcumin-modified soft liner exhibited a significant decrease in surface roughness compared with the unmodified liner. Both experimental ratios of curcumin; 10 and 20 v/v%, significantly enhanced both tensile bond strength of the liner to the denture base and antifungal activity. Conclusion: Curcumin has the qualities of a natural potent antifungal agent against oral candidiasis paired with denture soft liners. Moreoverits positive impact on surface roughness reduction and the increase in adhesion potential of the soft liner to the denture base has been verifiedClinical significance: The incorporation of curcumin into the denture soft liner seems to be a better alternative for oral candidiasis treatment to the incorporation of conventional antimicrobial drug regarding its antifungal activity, adhesion to the denture base, and surface roughness.