Abstract
A nosocomial outbreak by cefiderocol (FDC)-resistant NDM-1-producing Klebsiella pneumoniae (NDM-Kp) occurred in a large tertiary care hospital from August 2021–June 2022 in Florence, Italy, an area where NDM-Kp strains have become endemic. Retrospective analysis of NDM-Kp from cases observed in January 2021–June 2022 revealed that 21/52 were FDC-resistant. The outbreak was mostly sustained by clonal expansion of a mutant with inactivated cirA siderophore receptor gene, which exhibited high-level resistance to FDC (MIC≥32 mg/L) and spread independently of FDC exposure.
Cite
CITATION STYLE
Coppi, M., Antonelli, A., Niccolai, C., Bartolini, A., Bartolini, L., Grazzini, M., … Rossolini, G. M. (2022). Nosocomial outbreak by NDM-1-producing Klebsiella pneumoniae highly resistant to cefiderocol, Florence, Italy, August 2021 to June 2022. Eurosurveillance, 27(43). https://doi.org/10.2807/1560-7917.ES.2022.27.43.2200795
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
