AztD, a periplasmic zinc metallochaperone to an ATP-binding cassette (ABC) transporter system in Paracoccus denitrificans

Abstract

Background: AztD is an uncharacterized protein that may interact with AztABC, an ATP-binding cassette transporter of zinc. Results: AztD transfers zinc directly to AztC, the solute-binding protein of the AztABC system. Conclusion: AztD likely functions in zinc homeostasis by optimizing zinc transport through AztABC. Significance: Periplasmic zinc management by AztD is potentially important for zinc homeostasis across many Gram-negative species.