Overweight and Obesity, Cardiometabolic Health, and Body Composition: Findings From the Follow-Up Studies of the INCAP Longitudinal Study

Abstract

Background: There has been increased interest in the hypothesis that undernutrition in early life predisposes to cardiometabolic disease risk in adulthood. The Institute of Nutrition of Central America and Panama Longitudinal Study is able to address one critical aspect of this field, specifically whether improvements in nutrition can prevent this increased risk. Objective: To describe the main findings on obesity and body composition across 5 waves of field work (1988-1989, 1991-1994, 1998-1999, 2002-2004, and 2015-2017) and on cardiometabolic health across 3 waves (1998-1999, 2002-2004, and 2015-2017). Results: Body weight and body fat increased considerably in adulthood, especially among women with sedentary occupations. Adiposity and weight in adulthood were strongly predicted by weight gain after the first 1000 days of life. On the other hand, exposure to improved nutrition in early life reduced diabetes risk by approximately 50% but increased the risk of overweight and obesity. Conclusions: Future research will aid in clarifying the underlying mechanisms that drive the opposite associations among diabetes and obesity with early-life nutrition.