Risk of Paradoxical Rheumatoid Arthritis in Inflammatory Bowel Disease Patients Exposed to Tumor Necrosis Factor Inhibitors: A Propensity-Matched Multicenter Study

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Abstract

Tumor necrosis factor (TNF) inhibitor therapy for infammatory bowel disease (IBD) has been associated with an increased risk of rheumatoid arthritis and other infammatory conditions. Our retrospective study did not show an increased risk when compared with non-anti-TNF therapy for IBD.

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Keluth Chavan, A., Jha, P., Perez, J. A., Harper, E., Sinh, P., Cooper, G., … Mansoor, E. (2025). Risk of Paradoxical Rheumatoid Arthritis in Inflammatory Bowel Disease Patients Exposed to Tumor Necrosis Factor Inhibitors: A Propensity-Matched Multicenter Study. Inflammatory Bowel Diseases, 31(4), 1168–1173. https://doi.org/10.1093/ibd/izae203

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