Abstract
VCP/p97 is identified as a co-factor to the fusion oncoprotein ASPSCR1::TFE3. They co-localize on chromatin, co-dependent for enhancer looping and transcriptional regulation in alveolar soft part sarcomas and Xp11- rearranged renal cell carcinomas.
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CITATION STYLE
APA
Pozner, A., Li, L., Verma, S. P., Wang, S., Barrott, J. J., Nelson, M. L., … Jones, K. B. (2024). ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-45280-5
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