Lipiarmycin, a New Antibiotic from Actinoplanes. II. Isolation, Chemical, Bilogical and Biochemical Characterization

Abstract

Lipiarmycin, a metabolite of Actinoplanes deccanensis nov. sp. (Parenti et al.), has been isolated in pure form. It has a molecular formula C52-54H74-76Cl2O19, (M.W.=1, 073~1, 099). From its chemical and physico-chemical characteristics, lipiarmycin can be considered a new antibiotic. Lipiarmycin is highly active against Gram-positive bacteria, including strains resistant to the medically important antibiotics and protects mice experimentally infected with Streptococcus haemolyticus. Lipiarmycin inhibits growth of susceptible bacteria by interfering with RNA synthesis. © 1975, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.