Base-catalyzed electrophilic trifluoromethylthiolation of terminal alkynes

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Abstract

Pin the tail on the alkyne: CF3S- or CF3CF 2S-alkynes can be simply and quickly obtained by mixing terminal alkynes with a trifluoromethanesulfenamide reagent. The reaction uses easy-to-handle reagents, and functions under mild conditions without activation by transition metals. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Alazet, S., Zimmer, L., & Billard, T. (2013). Base-catalyzed electrophilic trifluoromethylthiolation of terminal alkynes. Angewandte Chemie - International Edition, 52(41), 10814–10817. https://doi.org/10.1002/anie.201305179

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