Association of MGMT promoter methylation with tumorigenesis features in patients with ovarian cancer: A systematic meta-analysis

Abstract

Background: The MGMT is a key tumor suppressor gene and aberrant promoter methylation has been reported in many cancers. However, the relationship between MGMT promoter methylation and ovarian cancer remains controversial. This meta-analysis was first conducted to estimate the clinical significance of MGMT promoter methylation in ovarian carcinoma. Methods: Literature search was performed in the PubMed, Embase, EBSCO and Cochrane Library databases. The pooled odds ratio (OR) and their corresponding 95% confidence interval (95% CI) were summarized. Results: Final 10 studies with 910 ovarian tissue samples were included in this meta-analysis. MGMT promoter methylation was significantly higher in ovarian cancer than in normal ovarian tissues (OR = 4.13, 95% CI = 2.32–7.33, p