Application of laparoscopic assisted digestive tract reconstruction in patients with gastric cancer: Impact on expression of cyclin D1 protein

Abstract

BACKGROUND At present, the incidence of gastric cancer (GC) in China is high and has been increasing year by year. Since the most effective treatment for GC patients is partial or total resection of the stomach, GC patients often require reconstruction of the digestive tract during surgery. With the continuous development of endoscopic techniques, it is very common to use gastroscopic techniques for reconstruction of the digestive tract in patients with GC. However, it is not very clear whether laparoscopic assisted digestive tract reconstruction can achieve the same efficacy as traditional digestive tract reconstruction. AIM To investigate the therapeutic efficacy of laparoscopic assisted gastrointestinal reconstruction in GC patients and the effect on the expression of Cyclin D1 protein. METHODS A total of 120 patients with GC who underwent elective laparoscopic total gastrectomy from May 2015 to May 2018 were randomly divided into either a study group or a control group, with 60 cases in each group. The study group underwent “P”-shaped jejunal loop with esophagojejunal Roux-en-Y anastomosis for the reconstruction of the digestive tract, and the control group underwent esophagojejunal Roux-en-Y anastomosis. The operation time, intraoperative blood loss, postoperative patient nutritional status, complication rate, and CyclinD1 protein expression were compared between the two groups. RESULTS There was no difference in intraoperative blood loss between the two groups (P > 0.05). The operation time and time to recovery of intestinal function were significantly shorter in the study group than in the control group (P < 0.05). Albumin, total protein, and hemoglobin levels in the study group were significantly higher than those of the control group (P < 0.05). The incidence of upper abdominal fullness and dumping syndrome in the study group was significantly lower than that of the control group (P < 0.05), while there was no significant difference in the incidence of diarrhea, reflux esophagitis, anastomotic stenosis, anastomotic bleeding, or pulmonary infection between the two groups (P > 0.05). The expression of Cyclin D1 protein was detected on the 7th day after operation, and all patients had negative results. There was no significant difference between the two groups (P > 0.05). CONCLUSION Laparoscopic gastrointestinal reconstruction after total GC resection is beneficial to the recovery of digestive function, improve the postoperative nutritional level of patients, and dose not increase the expression level of Cyclin D1 protein.