Suramin: a reversible P2‐purinoceptor antagonist in the mouse vas deferens

Abstract

The trypanocide Suramin was tested as a possible antagonist at the P2‐purinoceptor of the mouse vas deferens. At a concentration of 100 μm, Suramin antagonized the response to α,β‐methylene ATP, while responses to carbachol and noradrenaline were unaffected. These results suggest that Suramin may provide a starting point for the development of specific antagonists for P2‐purinoceptors. 1988 British Pharmacological Society