Clinical Study of Cardiac Arrhythmias Using a 24-Hour Continuous Electrocardiographic Recorder (5 th Report) - Antiarrhythmic Action of Coenzyme Q10 in Diabetics -

Abstract

Fujioka, T., Sakamoto, Y. and Mimura, G. Clinical Study of Cardiac Arrhythmias Using a 24-Hour Continuous Electrocardiographic Recorder (5 th Report)-Antiarrhythmic Action of Coenzyme Q10 in Diabetics- Tohoku J. exp. Med., 1983, 141, SuppL., 453-463——An investigation was undertaken to evaluate the antiarrhythmic effect of CoQI0 on VPBs using the Holter EGG, in 27 patients with no clinical findings of organic cardiopathies. As a result, the effect of CoQI0 on VPBs was considered beneficial in 6 (22%) of 27 cases, consisting of 1 patient with hypertension and 5 patients with DM. Even in the remaining 2 patients with DM, the frequency of VPBs was reduced by 50% or more during treatement with CoQI0. The mean reduction of VPBs frequency in the 5 responders plus these 2 patients with DM was 85.7%. These findings suggest that CoQI0 exhibits an effective antiarrhythmic action not merely on organic heart disease but also on VPBs supervening on DM.————cardiac arrhythmia; coenzyme Ql0. © 1983, Tohoku University Medical Press. All rights reserved.