The Effect of Oxidative Stress and Antioxidant Capacity on Postmenopausal Bone Mineral Densitometry

Abstract

Objectives: There are many mechanisms associated with the onset and development of osteoporosis.The purpose of our study is to investigate the relationship between the fasting blood sugar, lipid profile, bone mineral density (BMD) values, and total antioxidant status (TAS), total oxidant status (TOS) levels, and paraoxonase 1 (PON1), arylesterase (ARE) enzyme activities in postmenopausal women. Materials and Methods: Our study included 95 patients diagnosed as being postmenopausal. The patients were divided into three study groups, which were the control (T-score>-1; n=33 with normal BMD, osteopenia (-2.5 <0.05), whereas other parameters were not different among groups (p>0.05). Accordingly; the comparison of the control group with the osteopenia and osteoporosis groups revealed that serum PON1 enzyme activity was significantly increased in the control group (p<0.05). Conclusion: The results of the study suggest that increased age, duration of menopause, and oxidative stress, as well as decreased PON1 enzyme (an antioxidant enzyme) activity, lead to increased osteoporosis, independently of the lipid profile and serum fasting blood sugar.