Role of circular RNA in melanoma development: A mini review

Abstract

The Malignant melanoma, a tumor derived from melanocytes, shows severe drug resistance and prompt metastasis, causing a serious threat to human health. Emerging evidence indicates that circular RNAs are widely expressed in mammals and play crucial role in tumorigenesis by regulating micro RNA, downstream gene expression and protein production. The role of circular RNA in pathogenesis of melanoma has been recently reported and highlighted. This review makes and attempt to provide a better insight in to the role of circular RNA in melanoma.