Hybrid nanosystems for the treatment of infectious diseases produced by multidrug-resistant bacteria: A systematic review

Abstract

The rise of multidrug-resistant (MDR) bacteria poses a significant challenge to effectively treating infectious diseases. In recent years, nanotechnology has emerged as a promising approach to combat MDR bacterial infections. This systematic review, following the research guidelines proposed by PRISMA, aims to provide a comprehensive overview of the research conducted on hybrid nanosystems for the treatment of infectious diseases caused by MDR bacteria. Various categories of hybrid nanosystems combining different nanomaterials were investigated, including gold-, carbon-, and silver-based materials; iron oxide; copper oxide nanoparticles; liposomes; and polymers. Each category was thoroughly examined, and the studies were analyzed based on their methodologies, findings, and potential applications. The review highlights the progress made in the development of hybrid nanosystems, their unique properties, and their effectiveness in combating MDR bacterial infections. The findings from this systematic review provide valuable insights into the field of infectious disease management, aiding in the identification of potential nanosystem candidates for further development and clinical translation.