Abstract
Phenylpyruvic acid derivatives are obtained by hydrolysing aromatic Z/E azlactones. Keto tautomers interact with enzyme systems such as phenylalanine dehydrogenase or carboxypeptidase A whereas enol tautomers are potential inhibitors on the phenylpyruvate tautomerase activity catalysed by Macrophage Migration Inhibitory Factor (MIF). MIF being a key molecule in immune and inflammatory processes several structures with reasonable interaction with MIF and protocol for specific synthesis are presented. © Birkhäuser Boston 2004.
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CITATION STYLE
Carpy, A. J. M., Haasbroek, P. P., & Oliver, D. W. (2004). Phenylpyruvic acid derivatives as enzyme inhibitors: Therapeutic potential on macrophage migration inhibitory factor. In Medicinal Chemistry Research (Vol. 13, pp. 565–577). https://doi.org/10.1007/s00044-004-0102-y
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