Cytotoxic, fungicidal nucleosides from blue green algae belonging to the scytonemataceae

Abstract

Tubercidin, toyocamycin, and the corresponding 5′-α-D-glucopyranose derivatives of the nucleosides are frequently responsible for much of the cytotoxicity and antimycotic activity associated with extracts of cultured cyanophytes belonging to the family Scytonemataceae. The 5′-α-D-glucopyranoses of tubercidin and toyocamycin, for example, are the major cytotoxic and fungicidal nucleosides in Fijian Plectonema radiosum and Hawaiian Tolypothrix tennis, respectively. © 1988, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.