Role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in patients receiving hemodialysis

Abstract

We aimed to investigate the role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in patients receiving hemodialysis. Blood samples were collected from 216 patients receiving hemodialysis treatment. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype IL-6 -634C/G, -174G/C and -572C/G. By multivariate analysis, we found that the IL-6 -634GG genotype was associated with increased risk of cardiovascular events in patients receiving hemodialysis, with HR (95%CI) of 4.07 (1.20-15.70). Similarly, we found that the IL-6-174CC genotype was related to the onset and development of cardiovascular events in patients receiving hemodialysis, with HR (95%CI) of 3.33 (1.21-9.51). However, we did not find an association between IL-6 -572C/G polymorphism and risk of cardiovascular events in patients receiving hemodialysis. Our study suggests that IL-6 -634C/G and -174G/C polymorphisms are associated with risk of cardiovascular events in patients receiving hemodialysis.