Interleukin-10 inhibits lipopolysaccharide-induced tumor necrosis factor-α translation through a SHIP1-dependent pathway

Abstract

Background: IL-10 inhibits TNFα expression in the anti-inflammatory response. Results: IL-10 activates SHIP1 phosphatase to inhibit TNFα translation through polysome disassembly and Mnk1 activation. Conclusion: SHIP1 is involved in the regulatory mechanism of IL-10 for controlling TNFα translation. Significance: This suggests a STAT3-independent pathway for IL-10 in controlling inflammation through SHIP1. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.