Serum amyloid A regulates monopoiesis in hyperlipidemic Ldlr−/− mice

Abstract

We previously showed that feeding a Western-type diet (WTD) to Ldlr−/− mice lacking serum amyloid A (SAA) (Saa−/−Ldlr−/− mice), the level of total blood monocytes was higher than in Ldlr−/− mice. In this investigation we demonstrate that higher levels of bone marrow monocytes and macrophage-dendritic cell progenitor (MDP) cells were found in WTD-fed Saa−/−Ldlr−/− mice compared to Ldlr−/− mice and lower levels of GMP cells and CMP cells in Ldlr−/− mice. These data indicate that SAA regulates the level of bone marrow monocytes and their myeloid progenitors in hyperlipidemic Ldlr−/− mice.