Nafuredin, a novel inhibitor of NADH-fumarate reductase, produced by Aspergillus niger FT-0554

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Abstract

A novel compound, nafuredin, was isolated as an inhibitor of anaerobic electron transport (NADH-fumarate reductase). It was obtained from culture broth of Aspergillus niger FT-0554 isolated from a marine sponge. The structure was elucidated as an epoxy-δ-lactone with an attached methylated olefinic side chain on the basis of spectral analysis.

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Ui, H., Shiomi, K., Yamaguchi, Y., Masuma, R., Nagamitsu, T., Takano, D., … Omura, S. (2001). Nafuredin, a novel inhibitor of NADH-fumarate reductase, produced by Aspergillus niger FT-0554. Journal of Antibiotics, 54(3), 234–238. https://doi.org/10.7164/antibiotics.54.234

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