Regioselective chlorination and bromination of unprotected anilines under mild conditions using copper halides in ionic liquids

Abstract

By using ionic liquids as solvents, the chlorination or bromination of unprotected anilines at the para-position can be achieved in high yields with copper halides under mild conditions, without the need for potentially hazardous operations such as supplementing oxygen or gaseous HCl. © 2012 The Surface Science Society of Japan.