A case of molecularly profiled extraneural medulloblastoma metastases in a child

Abstract

Background: Extraneural metastases are relatively rare manifestations of medulloblastoma. Case presentation: We present the case of a young boy with group three MYCN-amplified medulloblastoma. He received multimodal chemotherapy consisting of gross total resection followed by postoperative craniospinal radiation and adjuvant chemotherapy. The patient developed extraneural metastases 4 months after the end of therapy. Literature review identifies the poor prognosis of MYCN-amplified medulloblastomas as well as extraneural metastases; we review the current limitations and future directions of medulloblastoma treatment options. Conclusion: To the best of our knowledge, this is the first molecularly characterized report of extraneural metastases of medulloblastoma in a child.