4‴-N-demethylspiramycin derivatives: Synthesis and evaluation of effectiveness against drug-resistant bacteria

Abstract

18-Amino-4″-O-benzoyl-4‴-N-demethyl-18-deoxospiramycins were designed and synthesized. Synthetic strategy involved selective demethylation of the dimethylamino group in forosamine, benzoylation of the hydroxyl group at the C4″ position and reductive N-amination of the formyl group. Antibacterial characteristics of spiramycin derivatives were tested. The derivatives exhibited promising activity against drug-resistant bacterial strains. © Japan Antibiotics Research Association.