Functional Regeneration Of The Visual System In Teleosts. Comparative Investigations After Optic Nerve Crush And Damage Of The Retina

Abstract

Goldfish and carp are shown to be capable of functional reconstitution of the visual system, although their neural retina except of the marginal growth zone at the ora serrata was completely destroyed by injection of the Na-K-ATPase inhibitor ouabain. This was demonstrated by the observation of the recovery of the optokinetic nystagmus after dam age of the retina. Recovery of vision coincides well with the morphological reconstitution of the visual system. The regenerated axons within the optic nerve are still unmyelinated at the mom ent of visual recovery, whereas some fibers within the stratum opticum pars profunda of the corresponding optic tectum are already myelinated. The recovery of vision after regeneration of the retina was compared with the recovery of vision after crush of the optic nerve. The range of tim e needed for visual recovery was smaller and better reproducible after crush than after dam age of the retina. © 1982, Walter de Gruyter. All rights reserved.