A CASE OF METASTATIC YOLK SAC TUMOR OF TESTIS IN A CHILD

Abstract

We report a case of testicular yolk sac tumor in a child aged 3 years and 6 months with multiple bulky metastases to lung and retroperitoneum (stage 11182). After three courses of chemotherapy with a PV 8 regimen (cisplatin, vinblastine and bleomycin). complete and partial responses were obtained for lung and retroperitoneal lymph node metastases, respectively. The patient was followed‐up closely. However, on the basis of a re‐elevated alpha‐letoprotein (AFP) after 4 months' follow‐up, he was treated with three courses of salvage chemotherapy with a modified VAB‐6 regimen (cyclophosphamide. etoposide. actinomycin D, bleomycin and cisplatin), lollowed by retroperitoneal lymph node dissection. Histologically, only necrotic tissue was found. There is no evidence of recurrence 24 months after lymphadenectomy. There is very little information in the literature on the appropriate management of postchemotherapy residual mass in pediatric testicular tumors. Copyright © 1995, Wiley Blackwell. All rights reserved