Pengembangan dan Evaluasi Formula Sediaan Patch Ekstrak Daun Binahong (Anredera cordifolia (Tenore) Steenis)

Abstract

Diabetic wounds are wounds that often occur in diabetics with common symptoms of hyperglycemia. Many plants owned by Indonesia have the potential to heal diabetic wounds, one of which is Anredera cordifolia (Tenore) Steenis. The Anredera cordifolia (Tenore) Steenis plant which is used to heal diabetic wounds, namely contain alkaloid compounds, flavonoids, saponins, tannins and triterpenoids. Anredera cordifolia (Tenore) Steenis leaves were extracted using the maceration method which then made a patch. Patch is one of the topical preparations that can deliver the drug to the wound site. Optimization bases used in this patch formula include HPMC, PVP, propylenglycol and 95% ethanol by adding the active substance with different concentrations of 35%, 40% and 45%. The patch formula is then subjected to physical evaluation to produce a stable and effective preparation, with storage temperatures include temperatures 1º-4ºC, temperatures 25º-28ºC, and temperatures 40ºC. The results of the physical evaluation test showed that storage at room temperature (25º-28ºC) was better and more stable, especially in the organoleptic test because it did not experience changes in shape, odor and color. The best weight uniformity test at F3 weighing 0,04 grams, the most stable pH test at F1 has a pH of 6 and is in accordance with the skin pH requirements, the best patch thickness test on F1 has 0,05 µm, and the patch fold resistance test which meets the requirements of ≥ 300 folds at F0, F1, F2. Based on all the physical evaluation tests conducted, F1 is the best and most stable preparation.