Abstract
HIV-1 Vif counteracts restrictive APOBEC3 proteins by targeting them for proteasomal degradation. To determine the regions mediating sensitivity to Vif, we compared human APOBEC3F, which is HIV-1 Vif sensitive, with rhesus APOBEC3F, which is HIV-1 Vif resistant. Rhesus-human APOBEC3F chimeras and amino acid substitution mutants were tested for sensitivity to HIV-1 Vif. This approach identified the α3 and α4 helices of human APOBEC3F as important determinants of the interaction with HIV-1 Vif.
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CITATION STYLE
Land, A. M., Shaban, N. M., Evans, L., Hultquist, J. F., Albin, J. S., & Harris, R. S. (2014). APOBEC3F Determinants of HIV-1 Vif Sensitivity. Journal of Virology, 88(21), 12923–12927. https://doi.org/10.1128/jvi.02362-14
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