Study of drug-nucleic acid interactions: 9-amino- [N-2-(4-morpholinyl) ethyl]acridine-4-carboxamide

Abstract

9-amino-[N-2-(4-morpholinyl)ethyl]acridine-4-carboxamide (9AMC) elicits its antitumour activity through intercalative binding with the genetic material, DNA molecule. The binding of this acridine molecule with DNA fragments has been examined using quantum mechanical methods. Second order perturbation theory valid for medium range interactions has been used to obtain binding sites of the acridine drug. Relative stability of various acridine-base pair complexes and preferred molecular associations have been discussed. © 2009 Springer Berlin Heidelberg.