Variability in the clinical distributions of Candida species and the emergence of azole-resistant Non-Candida albicans species in public hospitals in the midwest region of Brazil

Abstract

Introduction: Incidence and antifungal susceptibility of Candida spp. from two teaching public hospitals are described. Methods: The minimum inhibitory concentrations of fluconazole, voriconazole, itraconazole, and amphotericin B were determined using Clinical Laboratory Standard Institute broth microdilution and genomic differentiation using PCR. Results: Of 221 Candida isolates, 50.2% were obtained from intensive care unit patients; 71.5% were recovered from urine and 9.1% from bloodstream samples. Candida parapsilosis sensu stricto was the most common candidemia agent. Conclusions: We observed variations in Candida species distribution in hospitals in the same geographic region and documented the emergence of non-C. albicans species resistant to azoles.