Pore helices play a dynamic role as integrators of domain motion during Kv11.1 channel inactivation gating

Abstract

Background: Potassium channel pore helices are structurally important, but their contribution to the dynamics of inactivation gating is unclear. Results: Kinetic analysis reveals early and late pore helix motions during inactivation gating of Kv11.1 channels. Conclusion: Pore helices act as bidirectional integrators of domain motions during inactivation gating. Significance: Mechanistic insights into inactivation are crucial to understanding how Kv11.1 channels regulate cardiac electrical activity. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.