An efficient synthesis of pyrido[2,3-d]pyrimidine derivatives in ionic liquid

Abstract

(Chemical Equation Presented) A series of 5,7-diarylpyrido[2,3-d] pyrimidine-2,4(1H,3H)-diones was synthesized via the reaction of 6-aminopyrimidine-2,4-dione and α,β-unsaturated ketones in ionic liquid without using any catalyst. This protocol has the advantages of easier work-up, milder reaction conditions, high yields, and environmentally benign procedure over traditional methods. © 2010 HeteroCorporation.