Timing of diuretics in diuresis renography

Abstract

Purpose: The aim of this systematic literature review was to obtain an overview of when to administer the diuretics in relation to the radiopharmaceutical during a diuresis renography. Methods: A systematic literature search was performed in three different databases (Embase, PubMed/Medline and Cochrane Library) together with an information specialist. The review question was: when should diuretics be administered in relation to the radiopharmaceutical in a diuresis renography? Studies of adults were included together with guidelines published in collaboration with an organization. Results: Seventeen articles and four guidelines were retrieved in the literature search. The F − 15 method (diuretics administered 15 min before the radiopharmaceutical) was the one that was studied and described most and was compared with other time points for diuretic administration. The retrieved articles and guidelines report of advantages with different time points for diuretics. Both F − 15 and F + 0 are reported to clarify washout in equivocal cases compared to F + 20. Conclusion: No consensus could be found for a preferred time point of diuretics administration during a diuresis renography.