Preparo e caracterização de micropartículas de acetobutirato de celulose e poli(3-hidroxibutirato) contendo piroxicam

Abstract

This work aims to evaluate the influence of the cellulose acetate butyrate (CAB) molar weight and the addition of poly(3-hydroxybutyrate) [PHB] on microparticle morphology, encapsulation efficiency and release profile of piroxicam. The microparticles were prepared using the O/W emulsion/solvent evaporation technique and characterized according to the morphology using scanning electron microscopy. The drug content in the microparticles was determined through UV spectrophotometry and a dissolution assay was conducted using phosphate buffer pH 6.8. The obtained microparticles presented irregular shape; the ones prepared with CAB with large molar weight presented a larger size. Through a factorial design, it was observed that the analyzed variables (CAB molar weight and PHB addition) did not influence the encapsulation efficiency, but did influence the initial release of piroxicam from the microparticles.