Potensi Anti-inflamasi Fraksi Etil Asetat Ranting Patah Tulang (Euphorbia tirucalli L.) dengan Uji Penghambatan Denaturasi Protein

  • Abidin Z
  • Putri U
  • Widiastuti H
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Abstract

ABSTRAK Ranting Patah tulang (Euphorbia tirucalli L.) mengandung senyawa flavonoid berpotensi sebagai anti-inflamasi. Penelitian ini bertujuan untuk menentukan potensi anti-inflamasi fraksi etil asetat patah tulang dengan menggunakan uji penghambatan denaturasi protein. Penelitian ini terdiri dari tiga kelompok percobaan yang terdiri dari kontrol negatif, kontrol positif natrium diklofenak, dan fraksi etil asetat patah tulang sebagai kelompok uji. Potensi anti-inflamasi (IC50) natrium diklofenak memiliki nilai sebesar 26,46 µg/ml. Sedangkan fraksi etil asetat ranting patah tulang memiliki nilai IC50 sebesar 250,53 µg/ml. Hasil tersebut menunjukan bahwa ranting patah tulang berpotensi sebagai anti-inflamasi. Kata Kunci: Denaturasi Protein, Inflamasi, Ranting Patah Tulang (Euphorbia tirucalli L.). ABSTRACT The Milk bush (Euphorbia tirucalli L.) that contains flavonoids is potential to be anti-inflammation. The aim of this research was to determine the anti-inflammation potential of ethyl acetate fraction of milk bush by protein denaturation inhibition test. The research was implemented in three experimental groups, such as; negative control, sodium diclofenac as positive control, and ethyl acetate fraction of milk bush as test group. The potential of anti-inflammation (IC50) of sodium diclofenac has 26.46 µg/ml of IC50. Meanwhile, IC50 of ethyl acetate fraction of milk bush has 250,53 µg/ml. This result showed that the milk bush has the potential to be anti-inflammation.

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APA

Abidin, Z., Putri, U. A., & Widiastuti, H. (2020). Potensi Anti-inflamasi Fraksi Etil Asetat Ranting Patah Tulang (Euphorbia tirucalli L.) dengan Uji Penghambatan Denaturasi Protein. Ad-Dawaa’ Journal of Pharmaceutical Sciences, 2(2). https://doi.org/10.24252/djps.v2i2.11549

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