Nitric oxide in the treatment of critical conditions in newborns and premature infants

Abstract

Acute and chronic neonatal pulmonary hypertension accompany all critical syndromes in newborns, both congenital and acquired. Use of all selective vasodilators for newborns and premature infants is off-label in the Russian Federation. The aim of the paper is to structure data on the pathogenesis of acute and chronic neonatal pulmonary hypertension in newborns and premature infants; to determine the pathogenetic and clinical aspects of the use of inhaled nitric oxide in neonatology; and to describe the experience of using a fundamentally new technology for generating nitrogen oxide from air with the Tianox apparatus. Conclusion. Inhaled nitric oxide is a proven, high-quality rescue technology for acute and chronic neonatal pulmonary hypertension in newborns and preterm infants. Inhalantion of nitric oxide with the use of a nitric oxide generator is an affordable and the most thoroughly developed technique in this population.