How the ubiquitous GPCR receptor family selectively activates signalling pathways

  • Capper M
  • Wacker D
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Abstract

G-protein-coupled receptors activate different G-protein types to trigger divergent signalling pathways. Four structures of receptor–G-protein complexes shed light on this selectivity. G-protein-coupled receptors activate different G-protein types to trigger divergent signalling pathways. Four structures of receptor–G-protein complexes shed light on this selectivity.

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Capper, M. J., & Wacker, D. (2018). How the ubiquitous GPCR receptor family selectively activates signalling pathways. Nature, 558(7711), 529–530. https://doi.org/10.1038/d41586-018-05503-4

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