Synthesis of 1,3,4-thiadiazole derivatives and microbiological activities: A review

Abstract

Bacterial resistance associated to different antibiotics is a limitation for the treatment of infections and this has stimulated the development of new antimicrobial agents. In this aspect, novel 2,5- disubstituted-1,3,4-thiadiazole derivatives, which present a diversified biological activity, have been the focus of various research projects in recent the years. This article highlights the main methodologies for the synthesis of this heterocycle using acylhydrazines, dithiocarbazates, thiosemicarbazides, 1,3,4-oxadiazoles. Additionally, 2,5-disubstituted-1,3,4-thiadiazole derivatives with antimicrobial action are discussed.