Rescue pallidal stimulation for diphasic and stimulation-induced dyskinesia after successful subthalamic stimulation for Parkinson's disease

Abstract

A 64-year-old woman with Parkinson's disease who developed motor fluctuations, and both levodopa-induced and stimulation-induced dyskinesia, after long-term treatment of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS), underwent implantation of additional globus pallidus internus (GPi) DBS leads. Although an appropriate DBS target should be chosen, “rescue” GPi DBS can synergistically work with pre-existing STN DBS for the treatment of dyskinesia, which might provide a “third honeymoon.”.