Stem Cell Treatment for Diabetic Foot Ulcers: A Meta-analysis of Randomized Clinical Trials

Abstract

GENERAL PURPOSE To provide information on the efficacy of stem cells in the treatment of diabetic foot ulcers. TARGET AUDIENCE This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES After participating in this educational activity, the participant will: 1. Explain outcomes from the use of stem cell treatment for diabetic foot ulcers. 2. Identify features in the methodology of randomized controlled trials examining the efficacy of stem cells in the treatment of diabetic foot ulcers. OBJECTIVE To assess the efficacy of stem cells in the treatment of diabetic foot ulcers. DATA SOURCES The authors searched PubMed, EMBASE, Cochrane Library, and Clinical Trials databases. STUDY SELECTION The preliminary search identified 343 articles. After screening, 16 articles reporting 19 randomized controlled trials were included in the meta-analysis. DATA EXTRACTION The 16 articles included a total of 766 patients (400 in stem cell groups, 366 in control groups). Extracted data included: first author, publication date, patient characteristics, ulcer size, stem cell type and dose, follow-up time, evaluation index (eg, cure rate, amputation rate, pain-free walking distance), and adverse events. DATA SYNTHESIS The stem cell group had a higher ulcer healing rate compared with the control group (odds ratio [OR], 5.16; 95% CI, 3.60-7.40; P