AcrB is an inner membrane resistance-nodulation-cell division efflux pump and is part of the AcrAB-TolC tripartite efflux system. We have determined the crystal structure of AcrB with bound Linezolid at a resolution of 3.5 Å. The structure shows that Linezolid binds to the A385/F386 loops of the symmetric trimer of AcrB. A conformational change of a loop in the bottom of the periplasmic cleft is also observed. © 2013 The Author(s).
CITATION STYLE
Hung, L. W., Kim, H. B., Murakami, S., Gupta, G., Kim, C. Y., & Terwilliger, T. C. (2013). Crystal structure of AcrB complexed with linezolid at 3.5 Å resolution. Journal of Structural and Functional Genomics, 14(2), 71–75. https://doi.org/10.1007/s10969-013-9154-x
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