UNC93B1 and nucleic acid-sensing toll-like receptors mediate host resistance to infection with leishmania major

Abstract

Background: MyD88 is a critical element for host resistance to L. major. Results: UNC93B1 mutant and triple TLR3/7/9 knock-out mice are highly susceptible to infection with L. major. Conclusion: Nucleic acid-sensing TLRs are key sensors for Leishmania parasites. Significance: We disclose the mechanism by which L. major initiates IL-12 production and mediates development of Th1 lymphocytes and host resistance to infection. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.