Prognosis of chronic renal syndrome by classification and progression using temporal abstraction

Abstract

Chronic renal syndrome is defined as a progressive loss of renal function over period. Analysers have make effort in attempting to diagnosis the risk factors that may affect the retrogression of chronic renal syndrome. The motivation of this project helps to develop a prediction model for level 4 CKD patients to detect on condition that, their estimated Glomerular Filtration Rate (eGFR) stage downscale to lower than 15 ml/min/1.73 m². End phase renal disease, after six months accumulating their concluding lab test observation by assessing time affiliated aspects. Data mining algorithm along with Temporal Abstraction (TA) are confederated to reinforce CKD evolvement of prognostication models. In this work a inclusive of 112 chronic renal disease patients are composed from April 1952 to September 2011 which were extracted from the patient’s Electronic Medical Records (EMR). The information of chronic renal patients are collected in a big spatial info-graphic data. In order to analyse these info-graphic data, it is significant to detect the issues affecting CKD deterioration and hence it becomes a challenging task. To overcome this challenge, time series graph has been generated in this project work based on creatinine and albumin lab test values and reports of the time period. The presence of CKD diagnostic codes are transformed into default seven digit default format of International Classification of Disease 10 Clinical Modification (ICD 10 CM). Feature selection is performed in this work based on wrapper method using genetic algorithm. It is helpful for finding the most relevant variables for a predictive model. High Utility Sequential Rule Miner (HUSRM) is used here to address the discovery of CKD sequential rules based on sequence patterns. Temporal Abstraction (TA) techniques namely basic TA and complex TA are used in this work to analyse the status of chronic renal syndrome patients. Classification and Regression Technique (CART) along with Adaptive Boosting (AdaBoost) and Support Vector Machine Boosting (SVMBoost) are applied to develop the CKD in which the progression prediction models exhibit most accurate prediction. The results obtained from this work divulged that comprehending temporal observation forward the prognostic instances has escalated the efficacy of the instances. Finally, an evaluation metrics namely accuracy, sensitivity, specificity, positive likelihood, negative likelihood and Area Under the Curve (AUC) are helps to evaluate the performance of the prediction models which are designed and implemented in this project.