When knowing "enough" may still not be enough the mirage of suffcient understanding

Abstract

Many readers will be familiar with the highly pleio tropic nature of microRNAs (miRs), and also withthe diffculty inherent in defning exactly what constitutes their interactome and how this varies between cell types and environmental contexts. We describe recent advances that should assist with harnessing the potential of miRs to regulate cellular and cardiac behavior, but also re?ect on how the trap of assuming that we know enough may affect endeavors in mechanistic and therapeutic research.