Developmental toxicology

Abstract

Signs of Overt Maternal Toxicity 1. Daily (or isolated) body weight changes and/or effects on food and/or water consumption during the dosing perioda 2. Changes in respiration, alertness, posture, spontaneous motor activity, color of mucous membranes, behavior (aggressive, depressed, lethargic, sedated), hair and coat appearance, color of urine, frequency of urination, and number and consistency of fecal pellets 3. Other signs such as nasal discharge, chromodacryarrhea, salivation, vaginal bleeding, tumor, convulsions, and coma 4. Death and necropsy findings.