Some new pyrazole and pyrazolopyrimidines: Synthesis and antimicrobial evaluation

Abstract

Novel β-enaminonitrile of 1-(6-phenyl-pyridazin-3-yl)-pyrazole derivative 2 was formed using (6-phenyl-pyridazin-3-yl)-hydrazine (1) and 2-ethoxymethylene-malononitrile. The β-enaminonitrile derivative 2 was in turn used as precursors for the preparation of 1-(6-phenyl-pyridazin-3-yl)- pyrazoles (3, 9, 11), 1-(6-phenyl -pyridazin-3-yl)-pyrazolo[3,4-d]pyrimidines (4-8, 13-16) and some of their corresponding N-acyclic nucleosides (17, 18). All synthesized compounds were tested for their antimicrobial evaluation, and compounds 3, 9, 17, and 18 showed more significant activity than the other tested compounds and some known drugs (standers). © 2013 HeteroCorporation.