Nano-mechanical in-process monitoring of antimicrobial poration in model phospholipid bilayers

Abstract

Nanomechanical monitoring of known mechanisms of membrane poration mediated by host defense peptides is reported. Quartz Crystal Microbalance with Dissipation monitoring used to probe the process of antimicrobial poration in model phospholipid bilayers offers a straightforward method for mechanically differential kinetic measurements of membrane-mediated antimicrobial effects in situ.