Quest for safety at AAValon

Abstract

In this issue of Blood, Li and colleagues show an exhaustive, long-term safety assessment of adeno-associated virus (AAV) vector integration in mouse liver.1 Massive amounts of histopathologic, vector integration, and transcriptomic data provide a highly detailed view of the genomic impact of AAV vector integration in vivo. AAV vector integrations are not associated with tumor formation in these settings.