The effects on locomotor activity and reactivity of the hypoactive and inactive mutations of drosophila melanogaster

Abstract

Locomotor activity, expressed as walking and running, is reduced in adult flies by the mutant genes inactive, inactive2, hypoactive-C and hypoactive-E. The mutations iav and hypoC reduce both the amount and speed whereas hypoE reduces the speed but not the amount of locomotion. Stimulated activity, reactivity, and spontaneous activity are affected in different ways by these mutations. The frequency of jumping is greatly reduced by all four mutations, and the threshold for the jumping response appears to be related to speed of locomotor activity. The developmental profiles for locomotor activity of hypoactive and inactive mutants is described. © 1988, The Genetical Society of Great Britain.