Serum BDNF Concentrations Show Strong Seasonal Variation and Correlations with the Amount of Ambient Sunlight

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Abstract

Earlier findings show seasonality in processes and behaviors such as brain plasticity and depression that in part are regulated by Brain-Derived Neurotrophic Factor (BDNF). Based on this we investigated seasonal variation in serum BDNF concentrations in 2,851 persons who took part in the Netherlands Study of Depression and Anxiety (NESDA). Analyses by month of sampling (monthly n's >196) showed pronounced seasonal variation in serum BDNF concentrations (P

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Molendijk, M. L., Haffmans, J. P. M., Bus, B. A. A., Spinhoven, P., Penninx, B. W. J. H., Prickaerts, J., … Elzinga, B. M. (2012). Serum BDNF Concentrations Show Strong Seasonal Variation and Correlations with the Amount of Ambient Sunlight. PLoS ONE, 7(11). https://doi.org/10.1371/journal.pone.0048046

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